Immune Determinants of GD2 CAR T-Cell Activity in Patients with DIPG
Co-funded by the Violet Foundation for Pediatric Brain Cancer and Tough2gether Against DIPG/DMG
CAR T-cell therapy has shown success in treating certain types of cancer in children. This therapy trains the immune system’s T cells to locate and eliminate cancer cells. However, until recently, CAR T-cell therapy was not available for children with brain tumors like DIPG. In 2021, Stanford doctors, including Dr. Ramakrishna, initiated a clinical trial to use CAR T-cells for treating DIPG in children and young adults. Encouragingly, 10 out of 12 patients who received these CAR T-cells experienced tumor shrinkage and improvement in symptoms. This project aims to gain insights from patients to understand why CAR T-cell therapy succeeded or failed, with the aim of enhancing and optimizing the treatment.