We’re proud to share the publications that have emerged from ChadTough Defeat DIPG-funded research. Each study represents a step forward in understanding DIPG/DMG, improving treatments, and offering hope to families facing this devastating diagnosis.

2024 - 20 Publications

A road map for the treatment of pediatric diffuse midline glioma

 

Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma

 

PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma

 

Targeting Diffuse Midline Glioma with a novel anti-CD99 Antibody

 

An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma

 

DNA methylation landscapes in DIPG reveal methylome variability that can be modified pharmacologically

 

Understanding and therapeutically exploiting cGAS/STING signaling in glioblastoma

 

Mechanisms of telomere maintenance and associated therapeutic vulnerabilities in malignant gliomas

 

Sequential intravenous and intracerebroventricular GD2-CAR T-cell therapy for H3K27M-mutated diffuse midline gliomas

 

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice

 

Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

 

The oncolytic adenovirus Delta-24-RGD in combination with ONC201 induces a potent antitumor response in pediatric high-grade and diffuse midline glioma models

 

Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma

 

Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence

 

The rise of TIM‐3: A promising immune target in diffuse midline gliomas

 

Combination of locoregional radiotherapy with a TIM-3 aptamer improves survival in diffuse midline glioma models

 

Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201

 

GABA production induced by imipridones is a targetable and imageable metabolic alteration in diffuse midline gliomas

 

Rational combination platform trial design for children and young adults with diffuse midline glioma: A report from PNOC

 

A review of current therapeutics targeting the mitochondrial protease ClpP in diffuse midline glioma, H3 K27-altered

 

Liquid biopsy in H3K27M diffuse midline glioma

2023 - 16 Publications

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

 

Glioma synapses recruit mechanisms of adaptive plasticity

 

Targeting SWI/SNF ATPases in H3.3K27M diffuse intrinsic pontine gliomas

 

ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma

 

Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma

 

TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

 

Therapeutic avenues for targeting treatment challenges of diffuse midline gliomas

 

Cancer neuroscience: State of the field, emerging directions

 

Neuronal-Activity Dependent Mechanisms of Small Cell Lung Cancer Progression

 

Tumor inflammation-associated neurotoxicity

 

Ataxia-telangiectasia mutated (Atm) disruption sensitizes spatially-directed H3.3K27M/TP53 diffuse midline gliomas to radiation therapy

 

CAR T cell therapies for diffuse midline glioma

 

Efficacy of convection enhanced delivery of MTX110 (soluble panobinostat) in preclinical Diffuse Intrinsic Pontine Glioma models using metabolic hyperpolarized 13C imaging

 

Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways

 

Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations

 

Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma

2022 - 17 Publications

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

 

PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

 

VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system

 

Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma

 

GABAergic neuron-to-glioma synapses in diffuse midline gliomas

 

Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma

 

Structural variants shape driver combinations and outcomes in pediatric high-grade glioma

 

A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

 

Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome

 

Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas

 

Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma

 

Receptor tyrosine kinase (RTK) targeting in pediatric high-grade glioma and diffuse midline glioma: Pre-clinical models and precision medicine

 

GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas

 

Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003

 

Generation of immunocompetent syngeneic allograft mouse models for pediatric diffuse midline glioma

 

Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma

 

Epigenetically defined therapeutic targeting in H3G34R/V high-grade gliomas

2021 - 3 Publications

2020 - 3 Publications

2019 - 4 Publications

2018 - 2 Publications

We welcome the help of partners interested in funding promising research projects vetted by our renowned Scientific Advisory Council.

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